I believe that the HD44100 is an expansion chip to provide 2x8 character expansion for larger lcd panel, addition control would be needed to enable the extra lines.
Please see http://www.8052.com/tutlcd2.php
"The HD44780 or compatible controller is basically designed to build LCDisplays with one or two lines with a maximum of 40 characterpositions each. A single HD44780 is able to display two lines of 8 characters each. If we want more, the HD44780 has to be expanded with one or more expansion chips, like the HD 44100 (2 x 8 characters expansion) or the HD 66100 (2 x 16 characters expansion). Seen from the HD44780, the first line starts with 00h; the second line with 40h."
My design is for 1 or 2 line LCDisplay using a HD44780 or direct equivalent KS0066 (Samsung), or SED1278 (Epson). I can not determine if the HD44100 type is compatible with the lcd initiation code or indeed the characters sent. I suspect its not, but I do not have a lcd with that controller fitted so can't verify.
Sorry can't give positive yes or no answer!